The San Francisco 49ers have been dealing with all kinds of injuries to their pass catchers this season, but Brandon Aiyuk remains healthy. With Jauan Jennings ruled out, Deebo Samuel dealing with a wrist injury, and Ricky Pearsall likely seeing minimal work in his debut, plenty will fall on Aiyuk’s plate.

This will be the teams’ fourth meeting in the past six seasons – they have also played in two of the past five Super Bowls – and the Chiefs have won each of the previous matchups. Kansas City rallied to knock off San Francisco in overtime, 25-22, to win its second straight Super Bowl in February.