Brock Purdy’s three interceptions for the 49ers with no touchdown passes led to a career-low 36.7 passer rating.

San Francisco 49ers star Deebo Samuel has long been considered one of the best players, and best athletes, in the NFL, but ...

Kyle Shanahan evaluated the team's Week 7 loss to the Kansas City Chiefs and shared postgame injury updates on WR Brandon Aiyuk and others.

The San Francisco 49ers fear that wide receiver Brandon Aiyuk tore his right ACL on Sunday, according to coach Kyle Shanahan, ...

The San Francisco 49ers' Super Bowl hangover isn't going away easily, with the Kansas City Chiefs sending them below .500 on ...

The San Francisco 49ers lost standout receivers Brandon Aiyuk and Deebo Samuel during Sunday's 28-18 loss to the visiting ...

The 49ers were without three of their top playmakers for much of the matchup, with running back Christian McCaffrey (Achilles ...

The 49ers’ one, bonafide man-to-man beater at receiver, he became the No. 1 target after Deebo Samuel couldn’t play (illness) ...

With Jauan Jennings ruled out and Deebo Samuel dealing with an illness, the San Francisco 49ers lost another key pass catcher ...

Kareem Hunt rushed for two first half touchdowns Sunday as the Kansas City Chiefs became the only unbeaten team in the NFL ...

San Francisco 49ers K Anders Carlson scored his first 55-yard field goal as a member of the 49ers to beat his personal best record.

Pearsall came in for his first play on San Francisco’s opening drive and caught his first career pass late in the second quarter.